What was worrying is that it came with an added note saying that it was adequate for at least two years. A couple of weeks after the loading dose my blood was retested and came back with a B12 level of 2000 - not surprising as I’d had the loading dose. This is followed by 100 mg/kg in 1000 mL of D5W infused over 16 hours. My B12 level was very low <100 and after testing I was diagnosed with pernicious anaemia. 29,30 For example, piperacillin-tazobactam 4.5 g (30-minute infusion) should be followed in 6 hours by. Clearly, in the search for an optimal dosage scheme. What is the volume per hour that should be adminstered? Since the maximum concentration of drug (C max) is lower and the time for maximum concentration of drug (T max) is delayed with prolonged infusion, all dosing regimens should be initiated with a loading dose (dose infused over 30 minutes). This implies that, for similar inotropic support, larger bolus doses produced more hemodynamic instability. The maintenance dose is to be in 500mL of D5W over 4 hours. Desired concentration (Css) maintenance dose rate / CL 2. The second question is:īased on the information above (7350 mg) and the instructions the nurse received, what is the concentration of the maintenance dose that should be adminstered?Īm I missing something obvious again? Is the answer right there in the question? Intravenous infusion and intermittent intravenous bolus dosing equation 1. The first question was the one you helped me solve above. Follow this with a maintenance dose of 50mg/kg in 500 mL of D5W infused over 4 hours, then 100mg/kg in 1000 mL of D5W, infused over 16 hours.
I'll type the para and then I'll tell you what the prof is asking from the article.Īdminister an IV loading dose of 150 mg/kg of acetylcysteine in 200 mL of D5W, infused over 15 minutes. But wait! There's more! See, this was an article from Nursing magazine back in 2005. LD: 81-325 mg if already taking aspirin or 325 mg non-enteric aspirin if not taking aspirin MD: 75-100 mg daily with a P2Y12 inhibitor as part of DAPT.
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